Anorgasmia (often related to delayed ejaculation in males) is a form of sexual dysfunction sometimes classified as a psychiatric disorder in which the patient cannot achieve orgasm, even with adequate stimulation. However, it can also be caused by medical problems such as diabetic neuropathy, multiple sclerosis, genital mutilation or complications from genital surgery, pelvic trauma, hormonal imbalances, total hysterectomy, spinal cord injury, vulvodynia and cardiovascular disease. Anorgasmia is far more common in females than in males and is especially rare in younger men. Anorgasmia is the medical term for regular difficulty reaching orgasm after ample sexual stimulation, often causing significant sexual frustration. About 15% of women report difficulties with orgasm, and as many as 10% of women in the United States have never climaxed. Many women who orgasm regularly only climax about 50-70% of the time.

A common cause of anorgasmia, in both men and women, is the use of anti-depressants, particularly selective serotonin reuptake inhibitors (SSRIs). Though reporting of anorgasmia as a side-effect of SSRIs is not precise, it is estimated that 15-50% of users of such medications are affected by this condition. The chemical amantadine has been shown to relieve SSRI-induced anorgasmia in some, but not all, people.

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