Fidel Priestonn,
39 Bartok Bela korut Szombathely,
Szombathely 9700
Hungary
Last updated: October 14, 2010
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http://en.wikipedia.org/wiki/Aromatase
Aromatase is an enzyme that is responsible for a key step in the biosynthesis of estrogens. Because estrogens also promote certain cancers and other diseases, aromatase inhibitors are frequently used to treat those diseases.
Steroids are composed of four fused rings (labeled A, B, C, and D in the figure below). Aromatase transforms the left-hand ring (the A-ring) of steroids to an aromatic state (hence the name) through oxidation and subsequent elimination of a methyl group.
Aromatase is a member of the cytochrome P450 superfamily (EC 1.14.14.1), whose function is to aromatize androgens, producing estrogens. As such, it is an important factor in sexual development.
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Fidel Priestonn,
39 Bartok Bela korut Szombathely,
Szombathely 9700
Hungary
Last updated: October 14, 2010